Journal
NATURE REVIEWS CANCER
Volume 2, Issue 7, Pages 529-535Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc843
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Peutz-Jeghers syndrome (PJS) is a rare, inherited intestinal polyposis syndrome that is associated with a significantly increased risk of several types of cancer - particularly those of the gastrointestinal and reproductive systems. Most cases of PJS have been associated with loss-of-function mutations in the ubiquitously expressed LKB1 gene, which encodes a serine/threonine kinase. Recent studies have begun to illustrate the molecular mechanisms by which LKB1 functions as an important new tumour suppressor.
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