Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 59, Issue 7, Pages 1096-1116Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-002-8490-y
Keywords
fatty acid-binding protein; fatty acid transfer; site-directed mutagenesis; gene transcription; cancer; diagnostic marker; signal transduction
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Fatty acid-binding proteins (FABPs) are members of a superfamily of lipid-binding proteins, and occur intracellularly in vertebrates and invertebrates. This review presents recent findings on the diversity of these FABPs and their proposed roles in fatty acid (FA) metabolism and other cellular processes. Special attention is paid to the structural features of the different mammalian FABP types and the physiological role of these proteins in FA transport, cell growth and differentiation, cellular signalling, gene transcription and cytoprotection. Additionally, data on FABP knockout mice and the implication of FABP in medicine are discussed.
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