Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 2, Issue 8, Pages 1029-1044Publisher
ELSEVIER
DOI: 10.1016/S1567-5769(02)00057-7
Keywords
fatty acids; NK cells; nuclear hormone receptor; Th1/Th2 differentiation; transcription
Categories
Funding
- Intramural NIH HHS [Z01 BC009283-23] Funding Source: Medline
Ask authors/readers for more resources
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear steroid receptor superfamily. Originally, the receptors were identified as critical controllers for several key enzymes that catalyze the oxidation of fatty acids. PPARs consist of three members: PPAR-alpha, PPAR-beta/delta, and PPAR-gamma. Among them, PPAR-gamma is essential for controlling thermogenesis and adipocyte differentiation. The ligands for PPAR-gamma include 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2))-a metabolite from the prostaglandin synthesis pathway, and glitazones -drugs utilized in the treatment of patients with diabetes. The precursors for prostaglandins are fatty acids consumed from diet and these precursors have long been postulated to have a regulatory role in immune functions. Emerging evidence indicates that PPAR-gamma and its ligands are indeed important for the modulation of immune and inflammatory reactions. In this review, we will spotlight the molecular mechanisms of receptor/ligand function and how they may regulate immune and inflammatory reactions. We also propose that PPAR-gamma and its endogenous ligands are participating factors for Type 1 /Type 2 T and NK cell differentiation and development. Deciphering the mechanism of action of PPAR-gamma and its ligands may lead to a new therapeutic regiment for treatment of diseases involving dysfunction of the immune system. (C) 2002 Elsevier Science B.V All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available