Journal
JOURNAL OF APPLIED PHYSIOLOGY
Volume 93, Issue 1, Pages 271-279Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00323.2001
Keywords
altitude acclimatization; maximal exercise; autonomous nervous system; heart rate; propranolol; glycopyrrolate; oxygen uptake; acetylene uptake
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Funding
- NCRR NIH HHS [M01 RR-00827] Funding Source: Medline
- NHLBI NIH HHS [HL-17731] Funding Source: Medline
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After acclimatization to high altitude, maximal exercise cardiac output ((Q) over dot T) is reduced. Possible contributing factors include 1) blood volume depletion, 2) increased blood viscosity, 3) myocardial hypoxia, 4) altered autonomic nervous system (ANS) function affecting maximal heart rate (HR), and 5) reduced flow demand from reduced muscle work capability. We tested the role of the ANS reduction of HR in this phenomenon in five normal subjects by separately blocking the sympathetic and parasympathetic arms of the ANS during maximal exercise after 2-wk acclimatization at 3,800 m to alter maximal HR. We used intravenous doses of 8.0 mg of propranolol and 0.8 mg of glycopyrrolate, respectively. At altitude, peak HR was 170 +/- 6 beats/min, reduced from 186 +/- 3 beats/min (P +/- 0.012) at sea level. Propranolol further reduced peak HR to 139 +/- 2 beats/ min (P = 0.001), whereas glycopyrrolate increased peak HR to sea level values, 184 +/- 3 beats/ min, confirming adequate dosing with each drug. In contrast, peak O-2 consumption, work rate, and (Q) over dot T were similar at altitude under all drug treatments [peak (Q) over dot T = 16.2 +/- 1.2 (control), 15.5 +/- 1.3 (propranolol), and 16.2 +/- 1.1 l/min (glycopyrrolate)]. All (Q) over dot T results at altitude were lower than those at sea level (20.0 +/- 1.8 l/min in air). Therefore, this study suggests that, whereas the ANS may affect HR at altitude, peak (Q) over dot T is unaffected by ANS blockade. We conclude that the effect of altered ANS function on HR is not the cause of the reduced maximal (Q) over dot T at altitude.
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