Journal
ATHEROSCLEROSIS
Volume 197, Issue 2, Pages 922-930Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2007.08.012
Keywords
aging; C-reactive protein; polymorphism; genetic; susceptibility; aged; mortality; longevity
Funding
- NHLBI NIH HHS [N01-HC-85079, T32 HL007902, N01 HC035129, N01-HC-85086, U01 HL080295, N01-HC-75150, R01 HL071862-04, N01HC55222, T32 HL07902, N01 HC-55222, N01HC85086, N01HC85079, N01-HC-45133, R01 HL071862, N01 HC015103] Funding Source: Medline
- NIA NIH HHS [U19 AG023122-04, U19-AG023122, U19 AG023122] Funding Source: Medline
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Common polymorphisms in the CRP gene are associated with plasma CRP levels in population-based studies, but associations with age-related events are uncertain. A previous study of CRP haplotypes in older adults was broadened to include longevity and cause-specific mortality (all-cause, noncardiovascular (non-CV), and cardiovascular (CV)). Common haplotypes were inferred from four tagSNPs in 4512 whites and five tagSNPs in 812 blacks from the Cardiovascular Health Study, a longitudinal cohort of adults over age 65. Exploratory analyses addressed early versus late mortality. CRP haplotypes were not associated with all-cause mortality or longevity overall in either population, but associations with all-cause mortality differed during early and late periods. In blacks, the haplotype tagged by 3872A (rs1205) was associated with increased risk of non-CV mortality, relative to other haplotypes (adjusted hazard ratio for each additional copy: 1.42, 95% CI: 1.07, 1.87). Relative to other haplotypes, this haplotype was associated with decreased risk of early but not decreased risk of late CV mortality in blacks; among whites, a haplotype tagged by 2667C (rs1800947) gave similar but nonsignificant findings. If confirmed, CRP genetic variants may be weakly associated with CV and non-CV mortality in older adults, particularly in self-identified blacks. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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