Journal
FEBS LETTERS
Volume 522, Issue 1-3, Pages 3-5Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(02)02881-8
Keywords
carboxyhemoglobin; chloroquine; carbon monoxide; oxygen; malaria; Plasmodium falciparum
Ask authors/readers for more resources
To assess whether molecular oxygen and oxidative stress contribute to chloroquine activity, we cultivated strains of Plasmodium falciparum in erythrocytes with carboxyhemoglobin and an atmosphere containing 2% CO, 5% CO2 and 93% N-2. Results indicate that, contrary to common belief, oxygen is not involved in the activity of chloroquine. Reactive radicals formation is suggested. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
