Journal
FEBS LETTERS
Volume 522, Issue 1-3, Pages 6-8Publisher
WILEY
DOI: 10.1016/S0014-5793(02)02923-X
Keywords
alcohol dehydrogenase; futile cycle; respiration; chemostat; NADH channeling; Zymomonas mobilis
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A novel redox cycle is suggested, performing inter-conversion between acetaldehyde and ethanol in aerobically growing ethanologenic bacterium Zymomonas mobilis. It is formed by the two alcohol dehydrogenase (ADH) isoenzymes simultaneously catalyzing opposite reactions. ADH I is catalyzing acetaldehyde reduction. The local reactant ratio at its active site probably is shifted towards ethanol synthesis due to direct channeling of NADH from glycolysis. ADH II is oxidizing ethanol. The net result of the cycle operation is NADH shuttling from glycolysis to the membrane respiratory chain, and ensuring flexible distribution of reducing equivalents between the ADH reaction and respiration. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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