Journal
NEURON
Volume 35, Issue 1, Pages 147-159Publisher
CELL PRESS
DOI: 10.1016/S0896-6273(02)00753-5
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The relative contribution of kainate receptors to ongoing glutamatergic activity is at present unknown. We report the presence of spontaneous, miniature, and minimal stimulation-evoked excitatory postsynaptic currents (EPSCs) that are mediated solely by kainate receptors (EPSCkainate) or by both AMPA and kainate receptors (EPSCAMPA/kanate). EPSCkainate and EPSCAMPA/kainate are selectively enriched in CA1 interneurons and mossy fibers synapses of CA3 pyramidal neurons, respectively. In CA1 interneurons, the decay time constant of EPSCkainate (circa 10 ms) is comparable to values obtained in heterologous expression systems. In both hippocampal neurons, the quantal release of glutamate generates kainate receptor-mediated EPSCs that provide as much as half of the total glutamatergic current. Kainate receptors are, therefore, key players of the ongoing glutamatergic transmission in the hippocampus.
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