Journal
ATHEROSCLEROSIS
Volume 196, Issue 1, Pages 420-424Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2006.11.027
Keywords
Lp-PLA(2); n-3 fatty acids; coronary artery disease; adipose tissue; lipoproteins
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Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging risk factor for cardiovascular disease. In the present study, plasma levels of Lp-PLA(2) were measured in patients (n = 301) admitted to elective coronary angiography because of suspected coronary artery disease (CAD). In a multiple linear regression analysis, the degree of CAD (0-, 1-, 2- or 3-vessel disease) and plasma LDL cholesterol significantly correlated to Lp-PLA(2) levels. Also the content of the marine n-3 fatty acid, eicosapentaenoic acid (EPA) in adipose tissue, a measure of long-term intake of seafood independently and inversely (r= -0.18, p < 0.01) correlated with plasma levels of Lp-PLA(2) The results support the view that Lp-PLA(2) may relate to CAD and that intake of marine n-3 fatty acids might reduce plasma Lp-PLA(2) suggesting another mechanism by which n-3 fatty acids could reduce the risk of cardiovascular disease. (c) 2006 Published by Elsevier Ireland Ltd.
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