Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 277, Issue 27, Pages 24538-24545Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M203550200
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Nuclear localization sequence-dependent nuclear protein import is essential for maintaining cell function and can be selectively blocked in epithelial cells by mushroom (Agaricus bisporus) lectin. Here we report that a major intracellular ligand for this lectin is an N-terminally truncated form of oxygen-regulated protein 150 (Orp150), which lacks the endoplasmic reticulum translocation signal peptide of full-length Orp150. This cytoplasmic form of Orp150 expresses the lectin carbohydrate ligand (sialyl-2,3-galactosyl-,61,3-N-acetyl-galactosamine-alpha) and is shown to be essential for nuclear localization sequence-dependent nuclear protein import.
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