Journal
NEUROLOGY
Volume 59, Issue 1, Pages 118-120Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.59.1.118
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Funding
- NIA NIH HHS [AG05133] Funding Source: Medline
- NIMH NIH HHS [MH01489, MH57881, U01 MH46281, U01 MH46290, U01 MH46373, MH53459] Funding Source: Medline
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Although a portion of risk for late-onset AD (LOAD) is attributable to APOE, the search for other loci is ongoing. The authors hypothesize that psychotic symptoms with LOAD (LOAD+P) identify a potentially more etiologically homogeneous form of AD. Linkage analysis of families with LOAD+P identified one significant and several suggestive novel linkage signals, which bolsters the conjecture of greater etiologic homogeneity.
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