Journal
CELL
Volume 110, Issue 1, Pages 107-117Publisher
CELL PRESS
DOI: 10.1016/S0092-8674(02)00803-6
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The mammalian circadian system contains both central and peripheral oscillators. To understand the communication pathways between them, we have studied the rhythmic behavior of mouse embryo fibroblasts (MEFs) surgically implanted in mice of different genotypes. MEFs from Perl(-/-) mice have a much shorter period in culture than do tissues in the intact animal. When implanted back into mice, however, the Perl(-/-) MEF take on the rhythmic characteristics of the host. A functioning clock is required for oscillations in the target tissues, as arrhythmic clock(c/c) MEFs remain arrhythmic in implants. These results demonstrate that SON hierarchical dominance can compensate for severe intrinsic genetic defects in peripheral clocks, but cannot induce rhythmicity in clock-defective tissues.
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