Journal
SCIENCE
Volume 297, Issue 5579, Pages 211-218Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1071795
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Funding
- NIMH NIH HHS [F32 MH011390, F32 MH067462, F32 MH011390-03, P50-MH58880, P50 MH058880] Funding Source: Medline
- NINDS NIH HHS [R01 NS032925, R01-NS32925] Funding Source: Medline
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Pattern completion, the ability to retrieve complete memories on the basis of incomplete sets of cues, is a crucial function of biological memory systems. The extensive recurrent connectivity of the CA3 area of hippocampus has led to suggestions that it might provide this function. We have tested this hypothesis by generating and analyzing a genetically engineered mouse strain in which the N-methyl-D-asparate ( NMDA) receptor gene is ablated specifically in the CA3 pyramidal cells of adult mice. The mutant mice normally acquired and retrieved spatial reference memory in the Morris water maze, but they were impaired in retrieving this memory when presented with a fraction of the original cues. Similarly, hippocampal CA1 pyramidal cells in mutant mice displayed normal place- related activity in a full- cue environment but showed a reduction in activity upon partial cue removal. These results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall.
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