4.4 Article

Towards novel biolabels: synthesis of a tagged highly fluorescent Schiff-base aluminium complex

Journal

TETRAHEDRON LETTERS
Volume 43, Issue 29, Pages 5169-5171

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(02)00953-X

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Starting from 3-(4-hydroxyphenyl)propanoic acid, formylation ortho to the phenol and condensation with ortho-aminophenol gave a novel functionalised Schiff-base ligand. Formation of the N-hydroxysuccinimidyl ester and non-aqueous complexation with AlEt2Cl gave a novel fluorescent biolabel displaying a Stokes shift of 100 nm. The efficacy of the new system was demonstrated by its attachment to rabbit IgG. (C) 2002 Elsevier Science Ltd. All rights reserved.

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