Solid-phase synthesis of 1,4-diketones by thiazolium salt promoted addition of aldehydes to chalcones

The first report of thiazolium salt promoted Michael addition of aldehydes to chalcones (Stetter reaction) on solid-phase is reported. Reaction conditions have also been devised for cleaving the product 1,4-diketone from the solid-support in good yield and high purity. (C) 2002 Elsevier Science Ltd. All rights reserved.