Journal
BRAIN RESEARCH
Volume 945, Issue 1, Pages 135-138Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)02890-1
Keywords
cannabinoid receptor; morphine; conditioned place preference; opioid reward; CB1 receptor
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Funding
- NIDA NIH HHS [DA2412] Funding Source: Medline
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Recent reports have suggested an involvement of the brain cannabinoid system in the morphine-reward pathway. To address this question we evaluated whether CB I receptor knockout mice would show a conditioned place preference to morphine. CB I receptor knockout mice developed a strong place preference to 4 and 8 mg/kg morphine, similar to that in wild-type Swiss-Webster mice. This data thus does not support a contribution of the brain cannabinoid system to morphine reward. (C) 2002 Elsevier Science BY All rights reserved.
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