Journal
JOURNAL OF DERMATOLOGY
Volume 29, Issue 8, Pages 529-532Publisher
JAPANESE DERMATOLGICAL ASSOC
DOI: 10.1111/j.1346-8138.2002.tb00321.x
Keywords
anthralin; topical therapy; irritation; liposome; psoriasis
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We have prepared a novel, aqueous gel-based, liposome-entrapped formulation of dithranol. Herein, we report preliminary observations on its efficacy, tolerability, and cosmetic acceptability in treating stable plaque psoriasis. Nineteen plaques of psoriasis in nine adult patients were treated for six weeks in a prospective, open-label trial. In Five patients, there was total clearance of lesions, with more than 50% subsidence in a further two patients. Significantly, there were no reports of lesional or perilesional irritation, and only one patient showed faint brown staining of the skin, which was completely and rapidly reversible, These preliminary results indicate that our liposomal dithranol gel has potential advantages over presently available preparations of dithranol; these may translate into enhanced acceptance of this useful drug by patients and physicians.
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