Journal
ANTI-CANCER DRUGS
Volume 13, Issue 7, Pages 777-780Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001813-200208000-00013
Keywords
antidepressant agent; neuropathy; paclitaxel; pain; venlafaxine
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Venlafaxine is an antidepressant which acts through the inhibition of the reuptake of norepinephrine and serolonin. Venlafaxine is active against neuropathic and chronic pain. We report the case of a 69-year-old woman who presented a paclitaxel-induced neuropathy. She presented paresthesias, pin pricks in both hands with functional impairment. Venlafaxine hydrochloride was introduced at 37.5 mg twice daily. The patient noticed a dramatic recovery of her symptoms within 2 days, with both reduction of the paresthesias and functional improvement. This is the first report of efficacious use of venlafaxine for the treatment of paclitaxel cumulative neurosensory toxicity. [(C) 2002 Lippincott Williams Wilkins.].
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