Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 13, Issue 4, Pages 293-302Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/S1084952102000599
Keywords
alpha granule; dense granule; lysosome; platelet secretion; secretory pool disorders
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Funding
- NCI NIH HHS [2T32CA09078] Funding Source: Medline
- NHLBI NIH HHS [HL-64057] Funding Source: Medline
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Platelet granule exocytosis plays a critical role in thrombosis and wound healing. Platelets have three major types of secretory granules that are defined by their unique molecular contents, kinetics of exocytosis and morphologies. Although the ontogeny of Platelet granules is poorly understood, a convergence of new insights into megakaryocyte development, the molecular mechanisms of vesicle trafficking and the genetic basis of platelet granule defects, is beginning to define the cellular and molecular pathways responsible for platelet granule ontogeny.
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