Journal
CANCER IMMUNOLOGY IMMUNOTHERAPY
Volume 51, Issue 6, Pages 293-298Publisher
SPRINGER
DOI: 10.1007/s00262-002-0280-8
Keywords
cancer; immature myeloid cell; immune suppression; immune tolerance; T-cell response
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Impaired balance between mature and immature myeloid cells is one of the hallmarks of cancer. In cancer patients as well as in mouse models there is increasing evidence that progressive tumor growth is associated with an accumulation of immature myeloid cells, monocytes/macrophages, and with a decreased number and function of dendritic cells (DC). This review examines recent findings on the contribution of immature myeloid cells (ImC) to cancer-induced immune suppression.
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