Journal
NUCLEAR MEDICINE AND BIOLOGY
Volume 29, Issue 6, Pages 707-710Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0969-8051(02)00313-X
Keywords
C-60(OH)(x); Tc-99m-labeled; activity test; SPECT imaging; biodistribution
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The biological behavior of fullerene derivatives shows their considerable potential for medical applications. In order to provide a C-60 derivative for biodistriburtion studies, the Tc-99m-labeling of C-60(OH)(x) was optimized. Gamma counting and single photon emission computed tomography (SPECT) were used to assess the biodistribution of the Tc-99m-labeled compound in mice and rabbits. Biodistribution studies in mice and imaging of rabbits indicated that Tc-99m-C-60(OH)(x) was widely distributed in all tissues. A significant percentage of total activity was retained for 48 h, particularly in the kidneys, bone, spleen, and liver. All tissues displayed a slow clearance over 48 h, except for bone, which showed slightly increasing localization within 24 h. (C) 2002 Elsevier Science Inc. All rights reserved.
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