Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 1, Issue 8, Pages 573-586Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd871
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The increasing need to efficiently assemble small molecules as potential modulators of therapeutic targets that are emerging from genomics and proteomics is driving the development of novel technologies for small-molecule synthesis. Here, we describe some of the general applications and approaches to synthesis using one such technology - solid-supported reagents - that has been shown to significantly improve productivity in the generation of combinatorial libraries and complex target molecules.
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