Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 27, Issue 8, Pages 384-386Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(02)02140-0
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A previously undetected domain with a CxCx(n) CxH pattern of predicted zinc-chelating residues was identified in a variety of prokaryotic and eukaryotic proteins. These include bacterial ATPases of the SW12/SNF2 family, plant MuDR transposases and transposase-derived Far1 nuclear proteins, and vertebrate MEK kinase-1. This domain was designated SWIM after SW12/SNF2 and MuDR, and is predicted to have DNA-binding and protein-protein interaction functions in different contexts.
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