Estimation of the solubility of sulfonamides in aqueous media from partition coefficients and entropies of fusion

Semi empirical equation developed by Yalkowsky and Valvani, and another equation extended by Jain and Yalkowsky were used to estimate the aqueous solubility S-w, of some sulfonamides using experimental octanol-water partition coefficients P, entropies of fusion DeltaS(f), and melting points t(m), determined by DSC measurements. The calculated solubilities were compared with those experimentally determined. When experimental DeltaS(f) and t(m) were used, the S-w calculated values were in good agreement in most cases.