Journal
PHYSICS AND CHEMISTRY OF LIQUIDS
Volume 40, Issue 4, Pages 411-420Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/0031910021000017735
Keywords
sulfonamides; solubility; partition coefficient; Yalkowsky-Valvani and Jain-Yalkowsky equations
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Semi empirical equation developed by Yalkowsky and Valvani, and another equation extended by Jain and Yalkowsky were used to estimate the aqueous solubility S-w, of some sulfonamides using experimental octanol-water partition coefficients P, entropies of fusion DeltaS(f), and melting points t(m), determined by DSC measurements. The calculated solubilities were compared with those experimentally determined. When experimental DeltaS(f) and t(m) were used, the S-w calculated values were in good agreement in most cases.
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