Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 14, Issue 4, Pages 517-521Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(02)00356-4
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A selected fraction of plasmablasts enters the compartment of nondividing, long-lived plasma cells to maintain humoral antibody memory. In accord with a current model for lymphocyte homeostasis, the lifetime of long-lived plasma cells is probably regulated by competition for a limited number of survival niches present in splenic red pulp, bone marrow and inflamed tissue. Plasma cells secreting autoantibodies specific for some, but not all, self-antigens are probably 'allowed' to enter the compartment of long-lived plasma cells and provide anti body-mediated 'autoimmune memory' that is resistant to conventional therapies.
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