Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 129, Issue 1-2, Pages 74-83Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(02)00174-1
Keywords
wound healing; stress; mice; in situ hybridization; IL-1; KGF-1
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Funding
- NIA NIH HHS [P01AG16321] Funding Source: Medline
- NIDCR NIH HHS [P50DE13749, K08DE00409] Funding Source: Medline
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Stress has a negative impact on wound healing. This murine study evaluated the effect of restraint stress (RSI) on interleukin-1 (IL-1) and keratinocyte growth factor-1 (KGF-1) gene expression in cutaneous wounds by in situ hybridization, At day I, RSI trice had reduced frequency of IL-1beta mRNA-expressing fibroblasts compared to control mice. At day 3, RST mice had reduced frequencics of IL-1beta mRNA-expressing leukocytes, KGF-1 mRNA-expressing fibroblasts, and thin proliferating zones of epithelium. At day 5, RST mice had persistent leukocytic foci and reduced granulation tissue. Therefore, stress-induced alterations in cutaneous proinflammatory cytokine and growth factor expression are associated with significant histological changes in healing wounds. (C) 2002 Elsevier Science B.V. All rights reserved.
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