Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 12, Issue 4, Pages 441-446Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(02)00345-7
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The progress achieved by several groups in the field of computational protein design shows that successful design methods include two major features: efficient algorithms to deal with the combinatorial exploration of sequence space and optimal energy functions to rank sequences according to their fitness for the given fold.
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