Journal
PROSTAGLANDINS & OTHER LIPID MEDIATORS
Volume 68-9, Issue -, Pages 165-175Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0090-6980(02)00029-1
Keywords
COX-1; COX-2; knockout mouse
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The enzymes that convert arachidonic acid to prostaglandin H2 are named cyclooxygenase-1 (COX-1) and COX-2. The properties of COX-2 are different from those of COX-2. It was originally thought that the function of COX-1 was involved in physiological phenomena, whereas that of COX-2 was involved in various pathologies. However, studies with COX-2 knockout mouse suggest that COX-2 also plays important roles in development and homeostasis. This chapter focuses on the distinct functions of COX-1 and COX-2. (C) 2002 Elsevier Science Inc. All rights reserved.
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