Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 12, Issue 4, Pages 487-494Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(02)00352-4
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Funding
- NHLBI NIH HHS [HL54209, R01 HL054209, HL03502, HL60914] Funding Source: Medline
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Pulmonary surfactant functions by first flowing rapidly into the alveolar air/water interface, but then resisting collapse from the surface when the adsorbed interfacial film is compressed during exhalation. Widely accepted models emphasize the importance of phase behavior in both processes. Recent studies show, however, that fluidity is a relatively minor determinant of adsorption and that solid films, which resist collapse, can form by kinetic processes unrelated to equilibrium phase behavior.
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