Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 37, Issue 8, Pages 671-679Publisher
EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S0223-5234(02)01388-0
Keywords
diphenylpyrazole; nitrophenylpyrazole; azomethine; antiplasmodial activity; trichmonocidal activity; leishmanicidal activity
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1,3-Diphenylpyrazole-4-carboxaldehyde and 1-(4-nitrophenyl)-3-phenylpyrazole-4-carboxaldehyde were obtained from the appropriated phenylhydrazones via the Vilsmeier-Haack reaction. These two aldehydes were functionalized by various substituted anilines or substituted benzylamines. Antiparasitic activities of the corresponding azomethines were assessed. In the most cases, nitrated compounds were found to be more efficient than non-nitrated ones against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.
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