Journal
PROSTAGLANDINS & OTHER LIPID MEDIATORS
Volume 68-9, Issue -, Pages 211-234Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0090-6980(02)00032-1
Keywords
5-lipoxygenase; arachidonic acid; leukotriene; eicosanoid
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In this article, it has been attempted to review data primarily on the activation of human 5-lipoxygenase, in vitro and in the cell. First, structural properties and enzyme activities are described. This is followed by the activating factors: Ca2+ membranes, ATP, and lipid hydroperoxide. Also, studies on phosphorylation of 5-lipoxygenase, interaction with other proteins, and the intracellullar mobility of 5-lipoxygenase, are reviewed. (C) 2002 Elsevier Science Inc. All rights reserved.
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