Journal
CARBOHYDRATE POLYMERS
Volume 49, Issue 2, Pages 195-205Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0144-8617(01)00322-8
Keywords
chitosan; poly(amido amine); dendrimer; sialic acid; reductive N-alkylation
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Tetraethylene glycol was modified by two different approaches to synthesize the scaffold of dendrimer. Poly(amido amine) (PAMAM) dendrimers (G = 1-3) having tetraethylene glycol spacer were prepared and attached to chitosan by reductive N-alkylation. On chitosan molecules, the degree of substitution of dendrimers was 0.03-0.18. Sialic acid residue bound PAMAM dendrimers of each generation were successfully attached to chitosan. (C) 2002 Elsevier Science Ltd. All rights reserved.
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