Journal
CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE
Volume 6, Issue 4, Pages 329-334Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S1359-0286(02)00032-3
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Recent research into methods of using microelectromechanical systems (MEMS) technology for medical and biological applications has developed several interesting devices. This paper reviews various approaches to the use of MEMS for drug therapy, including devices based on microporous silicon, microneedles, micropumps, and microreservoirs. Microdevices can improve drug therapy because they allow precise and complex dosing, induce less pain, or increase compliance. Microneedles have been tested on humans, and the other drug delivery MEMS have shown promise in vitro and in vivo. Investigations into the use of microelectromechanical systems (MEMS) technology to produce microdevices for drug delivery have expanded recently. We present several different approaches to the use of microdevices for drug therapy and the current state of the field. (C) 2002 Elsevier Science Ltd. All rights reserved.
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