The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids

Generally the biosynthesis and degradation of compounds take place in separate subcellular compartments. The synthesis of 22 carbon acids, with their first double bond at position 4, requires anabolic enzymes in the endoplasmic reticulum as well as peroxisomal beta-oxidation enzymes. Partial degradation-resynthesis cycles, using enzymes in these two subcellular compartments, may play an important role in determining what PUFA are available for membrane lipid biosynthesis. (C) 2002 Elsevier Science Ltd. All rights reserved.