Journal
NATURE REVIEWS IMMUNOLOGY
Volume 2, Issue 8, Pages 580-592Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri856
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The receptors for the Fc of immunoglobulins, Fc receptors (FcRs), link the humoral and cellular, branches of the immune system, and they have important functions in the activation and down-modulation of immune responses. Balanced signalling through activating and inhibitory FcRs regulates the activity of various cells in the immune system. Recent work in animal models indicates that the-development of many human autoimmune diseases might be caused by impairment of the FcR regulatory system. This review provides an overview of the mechanisms of FcR-based immune regulation and describes how autoimmune disease might result from its dysfunction.
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