Journal
BRAIN AND COGNITION
Volume 49, Issue 3, Pages 268-276Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/brcg.2001.1500
Keywords
aging; Alzheimer's disease; brain weight; total number of neurons; dendrites; synaptic density; prefrontal cortex; hippocampus
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This article discusses age-related changes in brain weight, total number of cortical neurons, cortical dendrites, spine. and synapse density. The conclusion is that the present outlook is less grim than it was 30 years ago. Age-related reduction appears to he specific to brain region and cortical layer rather than general feature. In addition. we describe a different pattern of changes that occur in Alzheimer's disease patients. This review concludes that the association cortices in particular are affected in aging and Alzheimer's disease and that the primary visual and somatosensory cortices are relatively spared. (C) 2002 Elsevier Science (USA).
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