Journal
MECHANISMS OF DEVELOPMENT
Volume 116, Issue 1-2, Pages 183-186Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(02)00133-8
Keywords
Prickle; planar cell polarity; dishevelled; frizzled; Xenopus; morphogenesis; polarity; midline; pronephric duct
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We have cloned Xenopus orthologues of the Drosophila planar cell polarity (PCP) gene Prickle. Xenopus Prickle (XPk) is expressed in tissues at the dorsal midline during gastrulation and early neurulation. XPk is later expressed in a segmental pattern in the presomitic mesoderm and then in recently formed somites. XPk is also expressed in the tailbud, pronephric duct, retina, and the otic vesicle. The complex expression pattern of XPk suggests that PCP signaling is used in a diverse array of developmental processes in vertebrate embryos. (C) 2002 Published by Elsevier Science Ireland Ltd.
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