3.8 Article

Effects of dietary polyamines on the promotion of mammary tumor in rats

Journal

JOURNAL OF HEALTH SCIENCE
Volume 48, Issue 4, Pages 376-380

Publisher

PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/jhs.48.376

Keywords

carcinogenesis; 2-amino-1-methyl-6-phenylimidazo[4,5-b]; pyridine; polyamme; spermidine

Categories

Ask authors/readers for more resources

The effects of dietary polyamines have been investigated on 2-amino-1-methyl-6-phenylimidazo[4,5b] pyridine (PhIP)-induced carcinogenesis of the breast in rats by feeding spermidine (Spd) at three different concentrations. The cumulative incidence of mammary tumor in the group treated with PhIP plus Spd was 92% (low spermidine diet) and 68% (high spermidine diet), compared to 50 % in the PhIP group with a control diet. These results suggest that dietary polyamines may enhance the promotion of PhIP- induced mammary carcinogenesis. In addition, however, a low spermidine diet can promote the development of tumor in rats, but on the other hand a high spermidine diet may suppress the mammary carcinogenesis.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

3.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available