Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 13, Issue 4, Pages 263-270Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/S1084952102000551
Keywords
autophagy; exocytosis; multivesicular body; phospholipid transfer protein; secretory granules
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Funding
- NHLBI NIH HHS [P01-HL61646, P01-HL56387, R37-HL56285] Funding Source: Medline
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Lamellar bodies are members of a subclass of lysosome-related organelles referred to as secretory lysosomes. The principal constituents of the lamellar body, surfactant phospholipids, are organized into tightly packed, bilayer membranes in a process that is strongly influenced by the lung-specific, hydrophobic peptide SP-B. Newly synthesized SP-B is transported from the Golgi to the lamellar body via multivesicular bodies; in contrast, preliminary evidence suggests that newly synthesized surfactant phospholipids are transported from the ER and incorporated into the internal membranes of the lamellar body via a distinct pathway.
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