Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 12, Issue 4, Pages 441-446Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(02)00323-4
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SOX transcription factors perform a remarkable variety of important roles in vertebrate development, either activating or repressing specific target genes through interaction with different partner proteins. Surprisingly, these interactions are often mediated by the conserved, DNA-binding HMG domain, raising questions as to how each factor's specificity is generated. We propose a model whereby non-HMG domains may influence partner protein selection and/or binding stability.
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