Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 16, Issue 4, Pages 421-438Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/brbi.2001.0642
Keywords
development; lipopolysaccharide; mother-pup interaction; home cage activity; anxiety; exploration; response to novelty; stress; corticosterone; NPY; IL-6; IL-10; IFN-gamma; periodontal disease; Lewis rats
Categories
Ask authors/readers for more resources
The long-term consequences of neonatal lipopolysaccharide (LPS) exposure on adult behavioral and neuroendocrine stress responsiveness as well as on the clinical course of periodontal disease were assessed in male Lewis rats. At 3 and 5 days of age, pups were administered either saline (SHAM) or LPS or were left undisturbed. After postnatal treatment, mothers licked LPS-treated pups significantly more. In adult LPS rats, of 3-5 months of age, home cage activity indicated changes of the diurnal rhythmicity. Furthermore, SHAM- and LPS-treated animals displayed treatment-specific signs of increased anxiety in social interaction, elevated plus maze, holeboard, and open field tests. At 7 months of age, a dramatic increase of periodontal fiber loss in LPS rats was associated with increased plasma interleukin-6 levels. In contrast, SHAM treatment caused high plasma interferon-gamma cytokine levels and protective effects in periodontal disease. Parameters of the response to novelty were significantly correlated with later disease susceptibility. Thus, LPS-induced early postnatal illness modulates the adult behavioral responsiveness to stress and predisposes to periodontal disease. (C) 2001 Elsevier Science (USA).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available