Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 449, Issue 1-2, Pages 71-74Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(02)01985-4
Keywords
VMAT-2 (vesicular monoamine transporter-2); cocaine; methamphetamine; trafficking; (rat)
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Funding
- NIDA NIH HHS [DA04222, DA14475, DA00869, DA11389] Funding Source: Medline
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High-dose administration of cocaine or methamphetamine to rats acutely (less than or equal to 24 h) alters vesicular dopamine transport. This study elucidates the nature of these changes. Results reveal a differential redistribution of the vesicular monoamine transporter-2 (VMAT-2) within striatal synaptic terminals after drug treatment. In particular, cocaine shifts VMAT-2 protein from a synaptosomal membrane fraction to a vesicle-enriched fraction, as assessed ex vivo in fractions prepared from treated rats. In contrast, methamphetamine treatment redistributes VMAT-2 from a vesicle-enriched fraction to a location that is not retained in a synaptosomal preparation. These data suggest that psychostimulants acutely and differentially affect VMAT-2 subcellular localization. (C) 2002 Elsevier Science B.V. All rights reserved.
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