Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 196, Issue 3, Pages 303-310Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20020400
Keywords
FcRn; transcytosis; IgG; epithelial cells; lung
Categories
Funding
- NIAID NIH HHS [R01 AI053056] Funding Source: Medline
- NIDDK NIH HHS [DK0038, R37 DK048106, R01 DK044319, DK34854, DK/AI53056, P30 DK034854, DK48106, R01 DK048106, R37 DK044319, DK59945] Funding Source: Medline
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Mucosal secretions of the human gastrointestinal, respiratory, and genital tracts contain the immunoglobulins (Ig)G and secretory IgA (sIgA) that function together in host defense. Exactly how IgG crosses epithelia barriers to function in mucosal immunity remains unknown. Here, we test the idea that the MHC class I-related Fc-receptor, FcRn, transports IgG across the mucosal surface of the human and mouse lung from lumen to serosa. We find that bronchial epithelia cells of the human, nonhuman primate, and mouse, express FcRn in adult-life, and demonstrate FcRn-dependent absorption of a bioactive Fc-fusion protein across the respiratory epithelium of the mouse in vivo. Thus, IgG, like dimeric IgA, can cross epithelial barriers by receptor-mediated transcytosis in adult animals. These data show that mucosal surfaces that express FcRn reabsorb IgG and explain a mechanism by which IgG may act in immune surveillance to retrieve lumenal antigens for processing in the lamina propria or systemically.
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