Journal
JOURNAL OF CELL BIOLOGY
Volume 158, Issue 3, Pages 415-419Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200205011
Keywords
phagosome lysosome fusion; ADP ribosylation factor; type IV secretion; immune evasion; intracellular replication
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Phagosomes containing the bacterial pathogen Legionella pneumophila are transported to the ER after macrophage internalization. To modulate phagosome transport, Legionella use a specialized secretion system that injects bacterial proteins into eukaryotic cells. This review will focus on recent studies that have identified bacterial proteins and host processes that play a concerted role in transporting Legionella to the ER.
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