4.8 Article

Catalytic diastereoselective reductive Claisen rearrangement

Journal

ORGANIC LETTERS
Volume 4, Issue 16, Pages 2743-2745

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol026273b

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Funding

  1. NIGMS NIH HHS [GM064451] Funding Source: Medline

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[GRAPHICS] A catalytic amount of [(cod)RhCl](2) and MeDuPhos initiates an ester enolate Claisen rearrangement with good yields and diastereocontrol. Reaction conditions are mild and tolerant of base-sensitive functionality.

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