Decreased expression of glutathione peroxidase mRNA in thyroid anaplastic carcinoma

Our recent study using serial analysis of gene expression show the decreased expression of glutathione peroxidase (GPx), an antioxidant enzyme, in an anaplastic carcinoma. To clarify the expression of GPx in various kinds of thyroid tumors, the expression levels of GPx mRNA in 79 benign and malignant thyroid tissues were measured by means of real-time quantitative reverse transcription-polymerase chain reaction. A decreased expression of GPx mRNA was observed in all of five anaplastic carcinomas and some of the papillary carcinomas. A molecular-based therapy which produces O-2 radical may be considered as an alternative choice for the treatment of anaplastic carcinomas. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.