Journal
ONCOGENE
Volume 21, Issue 34, Pages 5213-5223Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1205684
Keywords
ICAM-1; MMP-9; tumor; proteases; cytotoxicity
Funding
- NCI NIH HHS [CA55735] Funding Source: Medline
- NIGMS NIH HHS [GM48614] Funding Source: Medline
Ask authors/readers for more resources
Shedding of intercellular adhesion molecule 1 (ICAM-1) is believed to play a role in tumor cell resistance to cell-mediated cytotoxicity. However, the mechanism whereby ICAM-1 is shed from the surface of tumor cells remains unclear. In this study, we have addressed the possibility that matrix metalloproteinases are implicated in ICAM-1 shedding. Our observations suggest a functional relationship between ICAM-1 and matrix metalloproteinase 9 (MMP-9) whereby ICAM-1 provides a cell surface docking mechanism for proMMP-9, which, upon activation, proteolytically cleaves the extracellular domain of ICAM-1 leading to its release from the cell surface. MMP-9-dependent shedding of ICAM-1 is found to augment tumor cell resistance to natural killer (NK) cell-mediated cytotoxicity. Taken together, our observations propose a mechanism for ICAM-1 shedding from the cell surface and provide support for MMP involvement in tumor cell evasion of immune surveillance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available