Journal
CELL
Volume 110, Issue 3, Pages 281-284Publisher
CELL PRESS
DOI: 10.1016/S0092-8674(02)00860-7
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Funding
- NIGMS NIH HHS [R37 GM038109] Funding Source: Medline
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The assembly and disassembly of macromolecular transcription complexes represents a key step in the regulation of gene expression. For inducible responses to hormones and stress, different combinations of molecular chaperones govern the activities of intracellular hormone receptors and heat shock transcription factor. Through their capacity to remodel the conformation of these activators, chaperones ensure tight control, dynamic range, and rapid reversible transcriptional response.
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