Journal
CELL
Volume 110, Issue 3, Pages 277-280Publisher
CELL PRESS
DOI: 10.1016/S0092-8674(02)00868-1
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The LINE-1 (L1) retrotransposon, the most important human mobile element, shapes the genome in many ways. Now two groups provide evidence that Ll retrotransposition is associated with large genomic deletions and inversions in transformed cells. If these events occur at a similar frequency in vivo, they have had a substantial effect on human genome evolution.
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