Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 67, Issue 16, Pages 5727-5732Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo0256888
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Funding
- NIGMS NIH HHS [5R01GM57123] Funding Source: Medline
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Efficient routes to three classes of 10-membered oxa-enediynes are presented. The electronic and stereoelectronic contributions to half-lives are supported by density functional theory calculations. One member of this class cyclizes to give an isochroman which binds to and degrades the aryl hydrocarbon receptor (AhR).
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